lab scientist
Other tech

Synthetic biology is a $30 billion opportunity creating 50,000 jobs according to CSIRO and its VC arm

- February 27, 2024 2 MIN READ

Synthetic biology – referred to as “synbio” by insiders – could develop industry worth billions of dollars, creating thousands more jobs that previously expected according to a new report by national science agency, CSIRO, and its venture capital fund, Main Sequence. The Synthetic Biology National Progress Report, released this week, is an update to the 2021… Read more »


Main Sequence, Steve Baxter back defence surveillance startup in $4.45m Seed round

- December 4, 2023 2 MIN READ

A defence tech startup that helps drones and airborne surveillance craft “see” better has raised $4.45 million in a Seed round. The investment in Arkeus was led by CSIRO deep tech VC Main Sequence, with participation from Steve Baxter’s new defence-focus fund, Beaten Zone Venture Partners, and Salus Ventures. The capital is allocated towards scaling… Read more »

Singer and investor Angus Stone, with Eden Brew CEO Jim Fader, and backer Bernard Fanning

Rock stars Bernard Fanning and Angus Stone, and Paralympian Dylan Alcott, back dairy replacement startup Eden Brew in $25 million Series A

- October 3, 2023 2 MIN READ

Dairy alternative startup Eden Brew has raised $24.4 million in a Series A as it prepares to bring its animal-free products, including milk and ice cream, to market.  The two-year-old venture, created as a joint-venture by northern NSW dairy co-op Norco, CSIRO and its VC arm, Main Sequence Ventures, uses a fermentation process to brew… Read more »

Dog, money, nurture

5 things Main Sequence’s Phil Morle learnt about venture capital from hanging out with 100 other investors

- August 29, 2023 4 MIN READ

Venture capital can be a solo, transactional game: meeting founders, building conviction, and making a case to an investment committee before allocating capital. Some firms learn how to exploit the aggregated super-power of their whole group to discover unique investments and unlock value. What we don’t talk about enough is how the firms themselves collaborate… Read more »

Michele Stansfield

Female-founded fermentation startup Cauldron lands $10.5 million to transform how new foods and fibres are developed

- March 27, 2023 2 MIN READ

Cauldron speeds up development of new food, feedstock and fibre ingredients Its hyper-fermentation platform lowers commercial risk & production costs $10.5m Seed round led by Main Sequence + Horizons Ventures An ambitious plan to transform the way new food, feedstock and fibre ingredients are created, by using fermentation has raised $10.5 million in seed funding… Read more »

robot typing
AI/Machine Learning

A VC analyst spoke to 50 AI startup founders to understand who to invest in – here’s what she found

- March 8, 2023 2 MIN READ

In my first few months working in deep-tech venture capital, I found and spoke to more than 50 founders building ‘AI’ companies. From climate to workflow to healthcare to transports and logistics to aged care, I canvassed the AI startup space in Australia, meeting incredible founders and gaining useful insight about the Australian AI ecosystem.… Read more »

money plant grow
Business strategy

5 reasons why every founder needs to make ESG part of their startup’s DNA

- February 9, 2023 2 MIN READ

ESG plans and action are increasingly expected from earlier-stage startups and are a non-negotiable requirement for later-stage companies gearing up to IPO. I’m a big believer that implementing ESG early can have a powerful positive effect on your company build.As an investor at Main Sequence, we have seen countless times companies who have a purposeful… Read more »


Bondi GP and angel investor Dr Amandeep Hansra joins Main Sequence as principal

- October 20, 2022 2 MIN READ

Sydney doctor, founder and angel investor Dr Amandeep Hansra has joined the CSIRO’s deep tech investment fund Main Sequence as a principal. Dr Hansra, a Bondi GP, has been in general practice for nearly two decades and co-founded the investment syndicate Australian Medical Angels, as well as founing Creative Careers in Medicine, which provides consulting services… Read more »

R&D, science, man looking in microscope

CSIRO’s VC fund Main Sequence is backing biotech startups in a new UNSW accelerator

- March 28, 2022 2 MIN READ

The University of NSW entrepreneurship program, UNSW Founders, will launch a new venture-backed accelerator for deep tech startups focused on synthetic biology and biotech with support from the CSIRO’s VC arm, Main Sequence. SynBio 10x will run in conjunction with the RNA Institute and UNSW School of Biotechnology & Biomolecular Sciences. Main Sequence will invest $120,000… Read more »